Monday, July 7, 2008

There is only one word for results like this: ouch!

The mysterious Condor has posted a (slightly enhanced, but presumably not in a data-changing fashion) graph summarizing a subgroup of an analysis on ENHANCE, and it showed that adding ezetimibe to a statin regimen didn't do any good. At all. The one apparently statistically significant good result for the 2nd quartile IMT looks spurious to me and really makes no sense except as a Type I error. Conversely, the statistically significantly bad result for the 3rd quartile looks like another Type I error. Overall, this look like nothing, or if anything a modestly negative effect.